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Chemotherapy drugs, such as irinotecan and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Salicylic acid is an acid that is also present in the medication aspirin. Doxapram was withdrawn and sinus rhythm returned 36 hours later site. The concentration returns to previous levels within 1–2 hours but, during this time, saliva serves as an important source of fluoride for concentration in plaque and for tooth remineralization ( 28).